From Boston/ Mass Pike and points east (3 hours):
Follow Route 2 West all the way to Williamstown. The Williams Inn is on the right of the Village Green at northerly junction of Routes 7 and 2. (3 hours)
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Take the Massachusetts Turnpike West (I- 90) to Exit 2, (Lee/Lenox). Follow Route 20 West to Route 7 North. Continue on Route 7 North through Pittsfield, Lanesboro, New Ashford and into Williamstown. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2. (3.5 hours).
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Take the Massachusetts Turnpike West (I-90) to (I-91) North and (I-91) North to Route 2 West. Route 2 West to Williamstown . As you follow Route 2 through Williamstown the Williams Inn is on the right of the Village Green at northerly junction of Routes 7 and 2. (3.5 hours)

From Albany(Capital District) New York and points west (1 hour):
New York State Thruway to Route I-87 North to Exit 6, Route 2 East in Latham. Take Route 2 East through Troy and over the mountain and down into Williamstown. Turn left at the southerly junction of Routes 2 and 7. Continue two miles north. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2.

From New York City(3.5 hours):
Henry Hudson Parkway North (1st Exit) to Sawmill River Parkway North to Taconic State Parkway North towards Albany. Take the last exit before toll, a right onto Route 295 East (Chatham & East Chatham) and continue until you come to the junction of Route 22. Turn left on Route 22 North and proceed until you come to the junction of Route 43 (at traffic light). Turn right on Route 43 East and proceed until you come to the junction of Route 7 (blinking light). Turn left and continue on Route 7 North to Williamstown. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2.

From New Jersey:

Take the Garden State Parkway to the Taconic State Parkway North towards Albany. Take the last exit before toll, a right onto Route 295 East (Chatham & East Chatham) and continue until you come to the junction of Route 22. Turn left on Route 22 North and proceed until you come to the junction of Route 43 (at traffic light). Turn right on Route 43 East and proceed until you come to the junction of Route 7 (blinking light). Turn left and continue on Route 7 North to Williamstown. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2.

Connecticut:

Take Route 7 North from Danbury to Williamstown. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2.
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Take Route 91 North to Massachusetts Turnpike West to Exit 2, (Lee/Lenox). Follow Route 20 West to Route 7 North to Williamstown. The Williams Inn is on the left of the Village Green at northerly junction of Routes 7 and 2.
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Take Route 91 North to Greenfield, and then take Route 2 West into Williamstown. The Williams Inn is on the right of the Village Green at northerly junction of Routes 7 and 2.